Despite demonstrated success and the promise of further discovery, funding for Zebrafish research is minimal, since its benefits are not as well known or understood as other biomedical research models. However, these small, transparent fish yield large quantities of statistically accurate, reliable and fast data for disease modeling and drug screening. The implications for medical research and scientific advancement are astounding. We hope that our documentary, Zebrafish: Practically People, Transforming How We Study Disease,  leads the way in educating the biomedical community and public about this small minnow and its big benefits in fighting human diseases.